Andy Murray and Stan Wawrinka were bundled out of the Monte-Carlo Masters on Thursday, but Novak Djokovic and Rafael Nadal reached the quarter-finals in contrasting fashion.
Albert Ramos-Vinolas fought back from 4-0 down in the final set to claim the scalp of top seed Murray, who went down 2-6 6-2 7-5 on the clay in the principality.
The world number one was not the only big name to bow out, as US Open champion Wawrinka was beaten 6-4 6-4 by Pablo Cuevas.
Twelve-time grand slam champion Djokovic showed he still has work to do in order to return to the peak of his powers, but saw off Pablo Carreno Busta 6-2 4-6 6-4.
Fourth seed and defending champion Nadal only needed 68 minutes to beat birthday boy Alexander Zverev 6-1 6-1.
MURRAY RUES 'BAD DECISIONS'
Murray looked bound for the last eight when he won the first four games of the deciding set, but the three-time grand slam champion was left stunned by a defiant Ramos-Vinolas.
The top seed grew increasingly disgruntled in the final set as Spaniard Ramos-Vinolas turned the tide to seal the biggest victory of his career and book a last-eight meeting with Marin Cilic.
Wimbledon champion Murray said: "A few times, I made some bad decisions. That's something that, with my team, I'll look at, watch some parts of the match over, see the shots that I chose and what I would do differently."
WOE FOR WAWRINKA
Cuevas had never beaten a top-four player before stepping out on court against Wawrinka, but needed just the two sets to put that record right.
The 16th seed from Uruguay did not face a solitary break point against the three-time grand slam champion in the first meeting between the two.
DJOKOVIC PASSES CARRENO BUSTA TEST
Djokovic was in danger of following Murray and Wawrinka out of the tournament, but hung in there to get past a defiant Carreno Busta and seal a clash with David Goffin.
It looked set to be plain sailing for the world number two when he won six games in a row to lead 2-0 in the second set, but the Spaniard was not finished yet.
Djokovic lost the next five games before Carreno Busta took it into a decider and the underdog had the Serb in trouble at 15-40 and 4-4 in the final set, but was unable to pull off a shock.
NADAL SPOILS THE PARTY
Nine-time Monte Carlo champion Nadal did not come bearing gifts on Zverev's 20th birthday, racing to victory in a one-sided contest.
The Spanish great broke five times as he won at a canter and will now face Diego Schwartzman, who reaches his first Masters quarter-final with a 6-3 6-0 demolition of Jan-Lennard Struff.
Lucas Pouille will take on Cuevas after the Frenchman was given an easy passage into the last eight, with compatriot Adrian Mannarino retiring due to a hip injury early in the first set.
|Bayern hand Bundesliga debut to Lars Lukas Mai|
|Costa should be back for Arsenal second leg, reveals Simeone|
|Wenger could coach Paris Saint-Germain, says Emery|
|Crusaders survive the storm, Chiefs inflict more misery on Reds|
|Wenger changed the face of English football - Dixon|
|Rodgers shrugs off Arsenal talk|
|Knights leave it late against Tigers, Cowboys end winless run|
|Austin track a disaster, says Rossi|
|Clash between top two ´more decisive´ for Napoli, Allegri claims|
|Chongqing sponsor ´positive´ over Iniesta deal|
|Valverde´s quiet crisis management leaves Barca ready to clean up|
|Wallabies centre Horne forced to retire|
|Vieira ´flattered´ by Arsenal link|
|Wenger was sacked by Arsenal, Wright claims|
|LeBron James: I won´t throw my team-mates under the bus|
|Dyche eager to feature in ´legendary´ Wenger´s Emirates farewell|
|Khan eyeing Brook fight later in 2018|
|United and City ´a million miles apart´, says Parker|
|Thorman slams dismal Giants display|
|Pogba must ´take more responsibility´, says Matic|
|Padres pitcher Ross´ no-hit bid steals spotlight|
|Cherry-Evans fined by Sea Eagles|
|Cavaliers blow lead as Raptors, Celtics lose|
|White Sox´s Farquhar faints in dugout, taken to hospital|
|Sporting Kansas City 6 Vancouver Whitecaps 0: Russell stars with hat-trick|
|Winslow fined $15,000 for stepping on Embiid´s mask|
|I don´t fear the challenge – Klopp eager to close gap to City|
|Johnson shares lead as Garcia misses cut in Texas|
|Career backup QB Luke McCown retires at 36|
|Texans ´optimistic´ about Clowney contract extension|
|Everybody wants to play under him – Ozil pays tribute to Wenger|
|Conte defends Chelsea record compared to Mourinho|
|LaLiga strugglers Espanyol show Flores the door|
|Messi is an alien but Sevilla can bring Barcelona back down to Earth, insists Montella|
|Four in a row for Wigan as Saints thrash Huddersfield|
|Reims´ latest vintage secure promotion to Ligue 1|
|Gloucester cruise into Challenge Cup final|
|Quiros claims one-shot lead despite rollercoaster round two|
|Millwall 0 Fulham 3: Sessegnon on target as Jokanovic´s side go second|
|Curry to begin modified practices on Saturday|
|Ancelotti welcomes Arsenal links, praises Wenger decision|
|Nadal produces ´best match of tournament´ as Dimitrov beats doubles partner|
|I think Arsenal would be good for a German coach - Podolski|
|Wilshere, Ramsey, Mertesacker and the best social media reaction to Wenger´s Arsenal departure|
|Watson haunts Royals with Super Kings hundred|
|Selby bracing himself for tough title defence|
|Exeter left ´disappointed´ by Ampadu transfer verdict|
|Froome thrilled with ´perfect´ build-up to Giro|
|Copa del Rey glory a good way to put European exit behind us, says Valverde|
|LMA hails Wenger´s impact at Arsenal|
|Wenger passes the torch as Arsenal face up to his formidable legacy|
|Gazidis: Arsenal cannot replace Wenger – we need a new path|
|Ronnie rivals never doubted Crucible attendance of ´snooker´s Tiger Woods´|
|Van Bronckhorst using Wenger´s methods at Feyenoord|
|Former NFL lineman Evan Mathis´ 1952 Mickey Mantle card sells for $2.88M|
|Wasps forward Johnson suspended for failed drugs test|
|I´d break another finger to win the Copa del Rey - Rakitic|
|Arsene Wenger: The Arsenal manager´s worst moments|
|Wright: More Arsenal changes needed after Wenger exit|
|Guardiola wishes Iniesta the best ahead of potential Barcelona exit|
|Real football people appreciate Wenger - Moyes, Warnock and more pay tribute|
|Guardiola set for contract talks with Manchester City|
|Controversial Slater score helps Storm to victory|
|Liverpool top, DVDs just invented and no Harry Potter – The world when Wenger joined Arsenal|
|Heynckes cannot compare Lewandowski and Ronaldo|
|Ronaldinho, Ronaldo, Messi, Mbappe and more – the stars Wenger claims he could have signed|
|Ferguson: Rival, colleague and friend Wenger is one of the greatest|
|Gattuso wary of challenge for Milan´s European place|
|Neuer returns to Bayern training after seventh-month absence|
|Wembley no advantage for Spurs in semi-final, warns Mourinho|