Worcester Warriors wing Josh Adams and Scarlets flanker James Davies are the two uncapped members of Wales' 39-man squad for the upcoming Six Nations.
Adams is the Premiership's top try-scorer this season with nine, while Davies - younger brother of centre Jonathan, who is absent with a serious foot injury - has impressed with the Scarlets.
Alun Wyn Jones will captain the side while Adams will have competition from the likes of Hallam Amos, Steff Evans, George North, Liam Williams and Alex Cuthbert for a starting spot on the wing.
Hooker Scott Baldwin is recalled while second-row Bradley Davies also comes back in, having not featured at all in 2017.
There is no place for centre Jamie Roberts, while record cap-holder Gethin Jenkins also misses out. Taulupe Faletau and Rhys Priestland are included despite carrying injuries.
Wales begin their campaign on February 3 at home to Scotland, who also announced their squad on Tuesday.
SQUAD NEWS Wales squad for 2018 @SixNationsRugby, led by @AlunWynJones and featuring two uncapped players in @JoshAdams951 and @cubbyboi. Llongyfarchiadau i'r bechgyn i gyd. https://t.co/SSg9bSLbku pic.twitter.com/ohFVocPDoE— Welsh Rugby Union (@WelshRugbyUnion) January 16, 2018
"It is an exciting opportunity for the two new caps. James' form over the last couple of years has been impressive, he's in a competitive area but we look forward to seeing what he can do," said head coach Warren Gatland.
"For Josh it's a great opportunity, he's been on great form and the back three is somewhere we are looking to create depth in.
"We have selected a larger squad and it is an opportunity for us to work with a wider group and continue building for the next 18 months. It's important to have a group of players who are used to the environment, know what is expected and are familiar with things and that will really benefit us going forward.
"We have included a couple of players who are carrying injuries. With Taulupe we are hoping he will be available towards the end of the campaign and Rhys picked up a knock at the weekend so we will see where he is at.
"It's useful to have these experienced guys around camp and to have them included and to work with them.
"Last autumn was about exposing and developing players as part of the two-year countdown to the Rugby World Cup, the next couple of months are about testing those players in tournament rugby - we know how important the Six Nations is."
Wales Six Nations squad:
Forwards: Scott Baldwin, Adam Beard, Bradley Davies, James Davies, Seb Davies, Elliot Dee, Rob Evans, Taulupe Faletau, Tomas Francis, Cory Hill, Ellis Jenkins, Alun Wyn Jones (captain), Wyn Jones, Samson Lee, Dillon Lewis, Ross Moriarty, Josh Navidi, Ken Owens, Aaron Shingler, Nicky Smith, Justin Tipuric.
Backs: Josh Adams, Hallam Amos, Gareth Anscombe, Dan Biggar, Alex Cuthbert, Aled Davies, Gareth Davies, Steff Evans, Leigh Halfpenny, George North, Hadleigh Parkes, Rhys Patchell, Rhys Priestland, Owen Watkin, Rhys Webb, Liam Williams, Owen Williams, Scott Williams.
|Warriors´ Cousins nearing NBA return|
|Pogba can´t do the basics – Souness criticises Man United star|
|Messi absence big blow for Barca as Icardi talks up Inter|
|´You can´t cry, that´s true´ – Ronaldo responds to Isco|
|Bartomeu: Barca still competitive without Messi|
|Bills RB McCoy remains in concussion protocol|
|Raiders place Marshawn Lynch on IR|
|Emery calm over title talk after another Arsenal win|
|Green: Warriors have to clean up defensively|
|Mariners say Bolt talks ongoing amid reports contract offer was rejected|
|Proud captain Ozil revels in Arsenal´s ´sexy football´|
|Puel angry over Holding handball|
|Cilic breezes through in Basel, Anderson fights back|
|Ingram: Four-game ban better than we expected|
|Raiders send Cooper to Cowboys for first-round pick|
|Arsenal 3 Leicester City 1: Outstanding Ozil inspires comeback win|
|World Series 2018: Three reasons why the Dodgers will win|
|Yarmolenko out for six months after Achilles surgery|
|World Series 2018: Three reasons why the Red Sox will win|
|Ozil eclipses Klinsmann to become Premier League´s most prolific German|
|Allegri expecting Old Trafford battle against Mourinho´s United|
|Bertens feared she did not belong in Kerber clash|
|Returning Ronaldo expecting ´tough´ game against Manchester United|
|Cristiano Ronaldo confident of clearing his name amid rape allegation|
|Osaka looking to learn from losing start in Singapore|
|Kovac expects tough test against AEK Athens|
|Whyte gives Chisora deadline over rematch|
|Spartak Moscow sack Massimo Carrera|
|Atletico Madrid confirm fresh injury issue for Gimenez|
|Dolberg extends Ajax contract after Real Madrid links|
|Ronaldo an example for Lukaku to follow|
|Bertens battles back to blast past Kerber|
|Ramos apologises for training ground fracas|
|Raikkonen should take heed of Alonso misfortune as F1 career winds down|
|Guardiola wants Manchester City fans to push team to Champions League glory|
|Isco not interested in departed Ronaldo - he didn´t want to be here|
|World Series 2018: Three storylines to watch in Red Sox-Dodgers|
|Neymar focus bad for football - PSG´s Maxwell|
|Marco Ianni charged by FA over Jose Mourinho touchline row|
|Stephens sees off Osaka in see-saw Singapore battle|
|I´m happy at Manchester United - Mourinho dismisses Real Madrid reports|
|Semenya and Asher-Smith head IAAF Female World Athlete of the Year shortlist|
|Mandzukic to miss Manchester United trip|
|I turned down Manchester United to return to Juventus - Bonucci|
|Sanchez out of Manchester United´s clash with Juventus|
|Australia make Short work of run chase in T20 win|
|Brotherly g-love! Tommy Fury follows Tyson into the pros|
|Ozil´s international retirement can help Arsenal - Emery|
|If you sack Lopetegui, you have to sack us all – Isco|
|Lopetegui defiant amid Real Madrid sack reports|
|Sri Lanka spinner Herath to retire after Galle Test|
|Ronaldo returns for Old Trafford welcome amid disquieting noise|
|Garcia claims third Andalucia Valderrama Masters title|
|Ex-England international Waldrom retires|
|´Massive personality´ Hart can lift Burnley, says Kompany|
|Liverpool felt wrath of ´emotional´ Klopp, says Shaqiri|
|Reid: Jenkins capitalised on Kaepernick movement|
|Manchester United v Juventus: Ronaldo out to end dismal scoring record against Mourinho|
|Injured Ribery to miss Bayern´s clash with AEK|
|Wilshere would have stayed at Arsenal under Wenger|
|Mahomes stars again as Chiefs crush Bengals|
|Bolt must accept ´much less´ to join Mariners, says A-League chief|
|Klopp compares Liverpool to dog without favourite toy|
|Young leads Hawks to first win, Thunder fall in Westbrook´s return|
|Spalletti hits out at physical Milan – I had three players asking to be replaced|
|Cowboys, Ravens lose after missed kicks in final seconds|
|Hernangomez secures Nuggets´ win over Warriors with last-second block|
|Hasler returns to Manly on three-year deal|
|Sarri: Chelsea fans must respect Mourinho|
|Ronaldo learnt from Scholes – Pjanic praises Juventus star|