Australia head to Twickenham with a spring in their step and eyeing revenge when they face England, while New Zealand take on Scotland and France host South Africa in another mouthwatering Saturday of international rugby.
England retained the Cook Cup by beating the Wallabies last year, but Michael Cheika's men are in fine form 12 months on and Eddie Jones' side must raise their game after a disjoined display in the win over Argentina.
World champions New Zealand head to Murrayfield on the back of being outplayed by France in the second half at Stade de France last weekend, having been outstanding in the opening 40 minutes to set up a victory in Paris.
Les Bleus will fancy their chances of seeing off a Springboks side that was hammered by Ireland, who should see off Fiji at the Aviva Stadium. Wales will aim to take the frustration of their latest loss to Australia out on Georgia.
With the help of Opta, we take a statistical look at the five Tests.
England v Australia
The Six Nations champions have won their last four matches against Jones' country of birth, including a 3-0 whitewash in Australia last year.
Australia have scored 55 tries in 2017, only twice have they scored more in a calendar year (64 in 2003, 56 in 1998).
England, who welcome Owen Farrell back into the side with Maro Itoje on the bench, are unbeaten in 12 games at Twickenham, their second-best sequence of victories at home. They won 22 in a row from October 1999 to September 2003.
France v South Africa
The Springboks whitewashed France 3-0 on home soil in June, all three victories by a margin of at least 22 points.
However, Les Bleus have come out on top in four of their last five home Tests against South Africa.
Antoine Dupont made four clean breaks, beat seven defenders and made 91 metres against New Zealand last Saturday. Since the 2015 Rugby World Cup, no tier one scrum-half has matched any of those statistics.
Ireland v Fiji
Joe Schmidt's side may not have expected to beat South Africa so emphatically, but they will be expected to rack up the points this weekend.
Ireland, who have handed a debut to centre Chris Farrell, have played only three Tests against Fiji, winning all three by 35 points or more.
Fiji wing Josua Tuisova has won 12 turnovers for Toulon in the TOP 14 this season, more than any other player in the competition this season, he's also crossed for five tries in his seven appearances.
Scotland v New Zealand
The All Blacks have never been beaten by Scotland in 30 Tests, only twice being held to a draw.
None of the current Scotland squad were born the last time they avoided defeat against the All Blacks – a 25-25 draw in 1983 – while Wyatt Crockett and Jerome Kaino are the only players in the world champions' touring squad to be born before that clash.
Scotland have won their last five matches at Murrayfield, their best winning sequence at the famous venue since a 13-game run from 1989 to 1991.
Wales v Georgia
This will be the first Test meeting between the two nations and Georgia will be looking for a first win against tier one opposition.
Wales missed just three of 153 attempted tackles [98 per cent success rate] against the Wallabies, the last time they missed fewer was in 2013 against Scotland. However, the 20 turnovers conceded was their highest figure in 15 matches.
Georgia full-back Soso Matiashvili scored 34 points against Canada last weekend, the most ever by a Lelos player in a Test match.
|Browns trade running back Hyde to Jaguars|
|Mourinho: I´d love to have Hazard at Manchester United|
|Hamilton´s title chances enhanced by Vettel´s grid penalty|
|Deja vu for Enisei as La Rochelle inflict another thrashing|
|Five-star Jovic makes Bundesliga history|
|Liverpool´s scoring slump no concern for cautious Klopp|
|He´s the Special One - Sarri insists he is not on Mourinho´s level yet|
|Second-half blitz guides Leicester to European success|
|Sheffield Wednesday 1 Middlesbrough 2: Besic, Assombalonga see off Owls|
|Goerges rallies to reach Luxembourg Open final, Jabeur makes history|
|Howe: Transfer speculation will not disrupt Ake|
|´Do we really want opera every night?´ - Klopp not changing Nations League view|
|Vile and abhorrent – Chelsea´s Carney responds to online abuse|
|Giants WR Beckham Jr. explains why he might cramp up: ´I really don´t like water´|
|Man City pay training-pitch tribute to Joe Hart|
|Neymar to be rested as Tuchel rubbishes Ballon d´Or concerns|
|Sarri ´not interested´ in Christensen father´s quit threat|
|Cardinals fire offensive coordinator McCoy after 1-6 start|
|Neymar return unlikely, but anything can happen – Valverde|
|Bairstow a doubt for fourth ODI|
|Manchester United fined for late arrival and delayed kick-off against Valencia|
|Australia-Pakistan chat not ´especially polite´ - Sarfraz|
|Pogba relishing ´pressure game´ against in-form Hazard|
|Don´t bet on Cardiff survival, warns Warnock|
|Buffon enjoying Tuchel´s methods at PSG|
|RIP to Wimbledon epics! Isner feels like The Undertaker following final-set tie-break rule|
|Sevilla performance sealed Bernat´s Bayern exit - Hoeness|
|Keita set to miss out as Liverpool monitor injured stars|
|He didn´t want to be here – Guardiola doubts Sancho will return to Manchester City|
|Sarri: Manchester United are the best in the Premier League|
|Mourinho salutes ´brave´ Shaw for ´best possible´ response to criticism|
|No Ballon d´Or distractions for Griezmann, insists Simeone|
|Wigan stand by Hardaker as full-back prepares to undergo rehabilitation|
|Barcelona deny Neymar talk|
|Hazard can win the Ballon d´Or as a Chelsea player, insists Sarri|
|De Bruyne in contention to start in Manchester City´s clash with Burnley|
|Neymar needs to mature to reach Messi levels - Xavi|
|We have a hell of a lot to do - Paine slams Australia batting|
|Kerber and Osaka to meet at WTA Finals|
|Lorenzo out of Japanese MotoGP|
|Real Madrid handed Africa trip in Copa del Rey|
|Allegri: Ronaldo has sharpened Juventus focus|
|No Wade in Wasps squad amid NFL reports|
|Rooney: Five of us controlled Man United dressing room|
|Bayern bosses launch scathing attack on ´disrespectful´ media|
|Saints lock in Lawes to new deal|
|Adelaide United 1 Sydney 1: Debutant Le Fondre rescues a point|
|Madrid can´t look back, only forward - Lopetegui confident of revival|
|Wimbledon to introduce final-set tie-breaks|
|Abbas inspires Pakistan to series victory|
|Madrid boss Lopetegui hopeful on Bale availability|
|Mood is positive at Bayern, insists under-pressure Kovac|
|LeBron offers food for thought after losing Lakers debut|
|Bolt future not an immediate concern for Mariners|
|Hazard: I could finish my career at Chelsea|
|Buffon hoping to avoid Champions League final against Juventus|
|Wilshere not ready for West Ham return|
|Chelsea v Manchester United: Hazard better under Sarri than he ever was with Mourinho|
|The big Friday Premier League quiz|
|Khawaja suffers meniscal tear, doubt for India series|
|Babbel: Klopp must win trophies now at Liverpool|
|LeBron makes spectacular start on Lakers debut, but LA fall to Trail Blazers|
|Broncos thrash Cardinals to end losing streak|
|Price leads Red Sox past Astros and into World Series|
|LeBron makes fast start on Lakers debut with two massive dunks|
|Real Salt Lake 4 New England Revolution 1: Hosts boost play-off chances|
|Simmons gets triple-double in win over Bulls|
|´Ambitious´ Maguire wants Champions League football|
|Henry praises ´charismatic leader´ Falcao|
|WATCH: Cardinals WR Fitzgerald tackles former QB Warner on sidelines|