Kubrat Pulev has been forced to pull out of his heavyweight title clash with Anthony Joshua due to a shoulder injury and will be replaced by Carlos Takam for the bout.
Unbeaten powerhouse Joshua was due to take on Bulgarian Pulev in his first fight since defending his IBF belt and claiming the WBA and IBO straps by defeating Wladimir Klitschko in an epic encounter at Wembley in April.
However, Pulev - the IBF's mandatory challenger - is not fit to participate in the bout, which was scheduled to take place in Cardiff on October 28, having strained muscles in a sparring session.
Promoters Matchroom confirmed the IBF's third-ranked fighter Takam as replacement for Pulev on Monday.
Update.. Kubrat Pulev has a shoulder injury and is out. IBF install IBF No.3 Carlos Takam as mandatory..deal done to fight AJ on October 28— Eddie Hearn (@EddieHearn) October 16, 2017
"I received a call from [Pulev promoter] Kalle Sauerland late afternoon today to inform me that Pulev had injured his shoulder and may be ruled out of the fight – this was later confirmed by his doctor," said Matchroom's Eddie Hearn.
"IBF rules state that the mandatory will go to the next fighter in line which is Carlos Takam."
Hearn also explained that Takam had been training for the fight in anticipation that Pulev could pull out.
"When the Pulev fight was announced I made a deal with Takam’s team to begin camp and be on standby for this fight.
"When I called them this evening they were overjoyed and good to go.
"It’s a difficult position for AJ having prepared meticulously for the style and height of Pulev, he now faces a completely different style and challenge in Takam – this hasn't happened in his career before but he is ready for all comers on October 28."
|Man City not Champions League favourites, insists Bernardo Silva|
|Isco calls for Modric to win Ballon d´Or after Champions League win|
|Wawrinka into last eight in St Petersburg|
|Goal hero Pogba is one of the best in the world - Shaw|
|Sane SOS can´t salvage sorry City display|
|Hoffenheim will learn lessons from Shakhtar draw, insists Nagelsmann|
|Valencia 0 Juventus 2: Pjanic hits the spot after Ronaldo sees red|
|Viktoria Plzen 2 CSKA Moscow 2: Krmencik heroics undone by late show|
|Benfica 0 Bayern Munich 2: Sanches returns to haunt his former club|
|Young Boys 0 Manchester United 3: Pogba double inspires Red Devils|
|Manchester City 1 Lyon 2: Cornet and Fekir stun Champions League favourites at home|
|Real Madrid 3 Roma 0: Isco stunner sets up winning start for Champions League holders|
|Ronaldo sent off on Champions League debut for Juve and may miss United reunion|
|Shakhtar Donetsk 2 Hoffenheim 2: Maycon denies Nagelsmann´s side|
|Ajax 3 AEK Athens 0: Tagliafico at the double in opening win|
|Dalot makes debut, Martial starts for Manchester United|
|India avenge ICC Champions Trophy loss with big win over Pakistan|
|Ronaldo makes Champions League debut for Juve|
|Lopetegui picks Navas over Courtois for Champions League clash with Roma|
|Willian very happy under Sarri after Conte row|
|Sarri deals blow to Chelsea kids´ Europa League hopes|
|Mendy out for Manchester City as Aguero makes bench|
|Cech accepts performances key to securing Arsenal stay|
|Monchi rules out Spain return amid Barcelona rumours|
|Durham skittled for 61 and 66 on the same day|
|Kane isn´t a machine – Lamela defends misfiring Spurs star|
|Hazard left out of Chelsea squad for PAOK trip|
|Tiger feels close to ending drought after achieving Tour Championship goal|
|Leno in line for Arsenal chance in Europa League|
|Gazidis leaves Arsenal in good shape, insists Emery|
|Eagles bring back WR Matthews, place Wallace on IR|
|England include Stokes, Hales and uncapped seamer Stone in ODI squad|
|Suwon Bluewings 0 Jeonbuk Motors 3 (aet, 4-2 on penalties): Quarter-final comeback ends in spot-kick|
|Australia captain Paine ready to slog it out with Pakistan|
|Nadal pulls out of China Open & Shanghai Masters with knee injury|
|Ostapenko begins Korea Open defence with victory|
|Joshua v Povetkin: How Olympic super heavyweight champions have fared|
|Liverpool ´made a point´ with PSG victory - Gomez|
|Osaka wows Tokyo crowd on WTA return|
|Excited Povetkin arrives in England for Joshua showdown|
|Kovac patience with Sanches set to reap rewards|
|Kovac: Madrid strong without Ronaldo, Messi is the best|
|ATP suspends umpire Lahyani over Kyrgios ´pep talk´ at US Open|
|North and South Korea seek to co-host 2032 Olympics|
|Ampadu signs long-term Chelsea contract|
|Don´t blame Neymar, PSG players all guilty - Thiago Silva|
|Real Madrid seek to plug Ronaldo scoring gap – Champions League in Opta numbers|
|Brewers allow Cardinals to inch closer with loss to Reds|
|Manchester is still red – Depay ahead of Lyon´s clash with City|
|Orioles become first pro team to wear braille jerseys|
|Klopp hails ´brilliant´ Henderson|
|PSG attack lacked aggression, says Tuchel|
|Atletico Tucuman 0 Gremio 2: Libertadores holders draw first blood in QFs|
|Thomas plays down wrist worry|
|Rakitic wants more from Barcelona hat-trick hero Messi|
|My players aren´t s*** – Pochettino defends Spurs squad|
|Cubs reliever Morrow won´t return this season|
|Tebow expected to be back in Mets organisation next season|
|Inter can compete against anyone – Icardi revels in Champions League victory|
|Tuchel: PSG loss to Liverpool not logical or correct|
|Sturridge in best shape I´ve seen – Klopp|
|Milojevic celebrates ´fantastic´ occasion after Red Star´s 26-year wait|
|Rodrigo and Simeone salute Griezmann display|
|Seahawks DE Clark on Bears QB Trubisky: He´s nothing special|
|Carroll says Wilson has been ´over-trying a little bit´|
|Judge returns to Yankees´ starting lineup|
|Napoli boss Ancelotti takes aim at Red Star time wasting|
|Favre admits young Dortmund stars struggled in Bruges|
|Otavio would trade goal for Porto victory as he bemoans Schalke draw|
|Championship Review: Pacesetters Leeds crush Preston, Villa end five-game winless run|