Manchester City defender John Stones warned his team their quadruple chase would take its toll as the season goes on.
City are still eyeing four trophies this campaign, although their bid to match the 'Invincibles' was ended with a Premier League loss to Liverpool earlier this month.
Stones said while manager Pep Guardiola would rest players when possible, the desire to win every competition was sure to play a part for City.
"We obviously wanted that [to go undefeated in the league], and I'm sure every team does, but it's such a difficult thing to do," the England international told UK newspapers.
"The four competitions we're still in, the amount of games compared to some other teams, you know it takes a toll, no matter how much you rotate the squad.
"I think sometimes you've got to hold your hands up and say, 'we gave it our best shot', which we did. I think we've just got to move on."
While City were beaten in the Premier League, they are still 12 points clear of rivals Manchester United at the top.
Stones denied suggestions the bid to go undefeated had put unnecessary pressure on Manchester City, who carry a 2-1 lead to Bristol City for the second leg of their EFL Cup semi-final on Tuesday.
"For me personally it wasn't an added pressure. I think you kind of want to make it happen, it's not so much a pressure, but on the other hand you could say it's a bit of pressure that's been released from us," he said.
"Some people might've been thinking it: could we go unbeaten and when is it going to happen?
"That could've been going through people's heads. From what I know it wasn't, it's one of those things where we've got to take it, re-evaluate, look at the game, look at positives, negatives, everything about it and go about business like we have been."
|West Brom future ´not a decision for me´, says Pardew|
|Lions get De Bruin off to winning start|
|Paris Saint-Germain 5 Strasbourg 2: Cavani at the double in bounce-back win|
|Bar-celona! Messi posts unwanted record|
|Barca go 31 LaLiga games unbeaten to tie club record|
|Mourinho: I don´t know and I don´t care when Pogba returns|
|Brighton and Hove Albion 3 Coventry City 1: Locadia, Ulloa lead Seagulls to quarter-finals|
|EIbar 0 Barcelona 2: Suarez and Alba seal points as Orellana sees red|
|West Brom 1 Southampton 2: Rondon stunner in vain as Baggies drop out|
|Wolfsburg 1 Bayern Munich 2: Lewandowski spot-on after Robben´s penalty miss|
|I hope Cutrone finds a beautiful girlfriend so he can rest and make love - Gattuso|
|Wellens claims Ruta del Sol lead, Froome suffers puncture|
|Goffin forced to retire in Rotterdam following freak eye injury|
|Allegri denies Champions League ´obsession´ ahead of Turin derby|
|Barry, Evans start for West Brom after training camp incident|
|Bottas unaffected by ´Halo´ on simulation runs|
|Sheffield Wednesday 0 Swansea City 0: Carvalhal settles for replay on Hillsborough return|
|Management ´tiring´ but Zidane not ready to leave Madrid just yet|
|Thiago back for Bayern as Heynckes rests stars for Besiktas|
|Simeone urges Atletico fans to get behind Griezmann|
|Robben amazed by Guardiola´s impact at Manchester City|
|Three-way tie for lead in Oman as Pavon falls away|
|McIlroy frustrated by added scrutiny of playing with Woods|
|Morgan to take it slow with Stokes and backs Rashid|
|Pogba out of Man Utd´s Huddersfield trip with illness|
|A-League Review: Perth ´Panenka´ punished, 10-man Adelaide rescue late draw|
|Dragons and Rabbitohs see off Super League opponents|
|Robben targets two more years at the ´highest level´|
|Rashford and Herrera ´have a chance´ of making Sevilla trip|
|Mixed feelings for Tiger Woods after missed cut at Riviera|
|Emery defends PSG star Neymar after Madrid display|
|Nishikori stays hot in New York as Anderson awaits|
|Kevin Durant: Laura Ingraham´s ignorant comment was racist|
|Thiem sets up Monfils semi-final showdown|
|Mahrez saga now over, says Leicester boss Puel|
|Cantlay, McDowell and Saunders top at Riviera as Woods makes early exit|
|Tiger Woods misses cut at Genesis Open|
|Astros manager Hinch on Cole: He doesn´t need to be fixed|
|Alonso to return for Barca clash but Bakayoko set to miss first leg – Conte|
|Mourinho: Manchester United will sign a midfielder|
|Record-breaking Federer rises back to summit, Goffin to meet Dimitrov|
|Kobe Bryant says Lakers ´shouldn´t need´ to recruit free agents|
|Federer pokes fun at himself after becoming oldest world number one|
|Woods to play Honda Classic as comeback continues|
|Glasgow Warriors book finals berth as Zebre upset Connacht|
|Conte given selection headache ahead of Barcelona clash|
|Atkins at the double as Warrington see off Widnes|
|Giroud ´relieved´ to get first Chelsea goal|
|Sarries scrap for Sale success|
|Records tumble in Federer´s latest remarkable ascent to the top|
|Chelsea 4 Hull City 0: Giroud scores and Willian stars as Blues reach last eight|
|Leicester City 1 Sheffield United 0: Vardy header secures quarter-final spot|
|Agassi congratulates Federer after losing rankings record|
|Kvitova to face Wozniacki after Goerges pulls out|
|I cry often and I cry alone - Buffon benefits from his emotional side|
|This one means the most - emotional Federer revels in return to the top|
|Mason retirement ´heart-breaking´, says Cahill|
|After five years and three months, Roger Federer is back on top of the world|
|Federer downs Haase to become oldest world number one|
|Imperious Kohli targets eight or nine more years after latest heroics|
|Halep withdraws from Doha with foot injury, Wozniacki stays No.1|
|Evans, Barry and Livermore among West Brom players to apologise for ´curfew breach´|
|Mahrez starts for Leicester City in FA Cup|
|Wozniacki wins gripping Kerber contest to keep No.1 spot|
|Vermaelen backs Chelsea-linked Luis Enrique for Premier League job|
|Low succeeding Heynckes at Bayern in 2019 is Matthaus´ ´dream´|
|Bellerin criticises ArsenalFanTV: How can that be a fan?|
|Froome focused on the road amid ´hyped up´ doping controversy|
|Juventus striker Higuain takes aim at critics again|
|Kohli breaks another record to slay South Africa|